A crash involving a Cleveland fire truck closed the right lanes of Interstate 71 southbound at West 150th Street around 11:30 a.m. Wednesday.
The off-ramp from I-71 to West 150th Street was also closed.
Cleveland fire spokesperson Larry Gray said two men from the car were transported to MetroHealth Medical Center for treatment of injuries. No firefighters were injured.
Hazmat was called to the scene to clean up leaked engine fuel.