The Cleveland Fire Department is investigating a fire that turned deadly on Wanda Avenue.
Crews were called to the scene around 4:45 a.m.
According to firefighters, a man in his 20s jumped out of an upstairs window to escape the flames. He was transported to the hospital in serious condition.
Firefighters said a woman in her 60s was found inside a second-floor bedroom and transported to Metro Hospital, where she later died.
Crews said the home is a total loss.
The cause of the fire is unknown at this time.