An 18-year-old and her 17-year-old boyfriend were wounded after shots rung through a bedroom overnight at 3550 East 154th Street, according to Cleveland police on Tuesday.
A family member said the bullets started in the front of the house and continued to its south side.
The girl was shot in her chest and wrist and the man was shot in the neck.
Both victims were taken to University Hospitals.
Detectives are investigating the incident.