A tow-truck driver towing a vehicle was hit by another car around 1:15 a.m. on I-90 westbound at East 72nd Street.
Cleveland EMS said that the 54-year-old tow truck driver was taken to University Hospitals in serious condition.
The driver of the car who hit the truck did not need to be taken to the hospital.
The highway was shut down for a couple of hours while crews investigated.
The cause of the crash is unknown.