CLEVELAND — University Hospitals announced Thursday its participation in a novel clinical trial testing multiple therapeutics to treat COVID-19 in adults who don’t require hospitalization.
University Hospitals said it is adding the ACTIV-2 Trial to its arsenal of investigational treatments. ACTIV-2 is a randomized, blinded, controlled study that tests a variety of new agents against placebo.
“This study aims to identify a treatment that can prevent people with COVID-19 from developing advanced disease that requires hospitalization,” said Grace McComsey, MD, Vice President of Research and Associate Chief Scientific Officer at UH in a news release. “UH is at the forefront of testing experimental treatments for COVID-19, including remdesivir, stem cell therapy and convalescent plasma. Patients suffering from complications of COVID-19 have hope at UH thanks to these options.”
This study is one of the few outpatient clinical trials in the Greater Cleveland Area.
“There is significant concern nationally as to how hospitals will handle the burden of both influenza and COVID-19 this winter,” said Mukesh K. Jain, MD, Chief Academic Officer at UH. “Studies focused on helping people recover from COVID-19 at home, without needing hospitalization, are vitally important and we hope our engagement in the ACTIV-2 trial will help us achieve this goal for our community.”
The first investigational agent to be evaluated by ACTIV-2 is an experimental monoclonal antibody treatment called LY-CoV555. This antibody was first identified by a blood sample taken from a patient in the U.S. who recovered from COVID-19.
One’s body produces antibodies to fight infections. Monoclonal antibodies are produced in a lab. LY-CoV555 is given as an infusion into a vein in the arm.
To qualify for the study, participants must have tested positive for SARS-CoV-2 infection in the outpatient setting within seven days and started experiencing symptoms within 10 days of enrolling into a study.
For information about enrolling in the trial at University Hospitals:
Call: 1-833-78-TRIAL
Email: ClinicalResearch@UHhospitals.org
Visit: uhhospitals.org/researchvolunteer
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